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Euchambersia was a therocephalian therapsid (a relative of mammals) that lived during the Late Permian period approximately 250 million years ago, in what is now South Africa.

Euchambersia was a unique therocephalian. It apparently had venom glands connected to its canine teeth. Like snakes, the teeth of Euchambersia were probably adapted to inject venom to kill its prey.

Euchambersia hunted dicynodonts like Lystrosaurus.